CJC-1295 (No DAC) is a synthetic research peptide that functions as a growth hormone–releasing hormone (GHRH) analog. It has been studied in laboratory settings for its ability to stimulate growth hormone (GH) secretion and insulin-like growth factor 1 (IGF-1) production. The “No DAC” designation means this version does not include the drug affinity complex (DAC) modification, resulting in a shorter half-life and different research applications compared to CJC-1295 with DAC. CJC-1295 (No DAC) continues to generate interest in endocrine and metabolic research models.

Area of Interest

Research into CJC-1295 (No DAC) has focused on several areas:

• Growth Hormone Studies: Evaluated for its ability to stimulate pulsatile GH release without extending activity through DAC binding.
• IGF-1 Modulation: Investigated for its influence on circulating IGF-1 levels in preclinical models.
• Endocrine Regulation: Studied as part of broader research into pituitary–hypothalamic signaling pathways.
• Comparative Research: Compared with CJC-1295 with DAC to understand differences in half-life, receptor binding, and activity windows.

Together, these areas highlight CJC-1295 (No DAC) as a valuable tool for understanding growth hormone regulation in research environments.

Technical Information

• Chemical Name: CJC-1295 (No DAC)
• Synonyms: Modified GRF (1-29), tetrasubstituted GRF (1-29)
• Molecular Formula: C₁₆₅H₂₇₁N₄₇O₄₆
• Molecular Weight: ~3367.9 g/mol
• Sequence (Amino Acid): Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn
• CAS Number: 863288-34-0
• Peptide Classification: Synthetic growth hormone–releasing hormone analog

Storage Guidelines

• Lyophilized peptide is stable at room temperature for short periods.
• For long-term storage, keep at −20 °C or below.
• Once reconstituted, store at 2–8 °C. Effective use depends on the solution used.

Solubility

CJC-1295 (No DAC) is soluble in sterile water, acetic acid, or other aqueous buffers depending on formulation.

References

• Teichman, S. L., Neale, A., Lawrence, B., et al. (2006). “Prolonged stimulation of GH and IGF-I secretion by CJC-1295, a long-acting GHRH analog.” Journal of Clinical Endocrinology & Metabolism, 91(3), 799–805. https://doi.org/10.1210/jc.2005-1536
• Research peptides database entries for Modified GRF (1-29).