Selank is a synthetic research peptide developed as an analogue of the naturally occurring tetrapeptide tuftsin. Unlike tuftsin, Selank has been engineered for greater stability and longer activity in laboratory settings. It has attracted strong interest in preclinical and experimental studies for its potential roles in mood regulation, cognitive performance, and neuroprotection. Selank is not approved for therapeutic use, but it continues to be actively investigated as an exciting candidate for research into brain and behavioral sciences.

Area of Interest

Research into Selank has explored several promising areas:

• Anxiolytic Studies: Investigated for its ability to modulate the balance of neurotransmitters such as GABA and serotonin in models of stress and anxiety.
• Cognitive Research: Preclinical work suggests possible enhancement of learning, memory, and attention in laboratory animals.
• Immune Modulation: Explored for effects on cytokine expression and immune system pathways, highlighting potential overlap between neurological and immune research.
• Neuroprotection: Studied in models of oxidative stress and neurotoxicity, where it may help protect neurons from damage.

These diverse areas of research keep Selank at the forefront of laboratory investigations into the interface between neurochemistry, cognition, and behavior.

Technical Information

• Chemical Name: Thr-Lys-Pro-Arg-Pro-Gly-Pro
• Synonyms: TP-7, Selanc, Tuftsin analogue
• Molecular Formula: C₃₃H₅₇N₁₁O₉
• Molecular Weight: ~751.9 g/mol
• Sequence (Amino Acid): TKPRPGP
• CAS Number: 129954-34-3
• Peptide Classification: Synthetic heptapeptide analogue of tuftsin

Storage Guidelines

• Lyophilized peptide is stable at room temperature for short periods.
• For long-term storage, keep at −20 °C or below.
• Once reconstituted, store at 2–8 °C. Effective use period may vary depending on the solution used.

Solubility

Selank is soluble in sterile water and aqueous buffers depending on formulation and purity.

References

• Inozemtsev, A. N., Kamensky, A. A., et al. (2008). “Peptide Selank: behavioral and neurochemical studies.” Doklady Biological Sciences, 418(1), 21–24. https://doi.org/10.1134/S0012496608010057
• Ashmarin, I. P., Kamensky, A. A., & Myasoedov, N. F. (1995). “Tuftsin analogues and brain function: development of Selank.” Peptides, 16(6), 1093–1098. https://doi.org/10.1016/0196-9781(95)00070-9
• Andreeva, L. A., Inozemtsev, A. N., & Kamensky, A. A. (2010). “Selank and immune modulation in experimental models.” Neurochemical Journal, 4(3), 167–171. https://doi.org/10.1134/S1819712410030050