Chemical Identifier: Lysine-Proline-Valine (C-Terminal Fragment)

KPV is a naturally occurring tripeptide derived from alpha-melanocyte-stimulating hormone (alpha-MSH). In laboratory settings, this specific amino acid sequence (Lys-Pro-Val) is identified as the primary active component responsible for the immune-modulating properties of the parent hormone, without the pigment-stimulating side effects.

Tide Labs supplies high-purity, lyophilized KPV (5mg) for use in controlled research environments investigating cellular inflammatory pathways and microbial interactions.

Areas of Investigation

KPV is a subject of high interest in gastroenterology and dermatology research due to its specific interaction with inflammatory mediators:

• Systemic Inflammation (The NF-κB Pathway): Research suggests KPV may modulate the NF-κB pathway, acting as a “switch” that regulates immune response. Studies investigate its potential to stop inflammatory signals from entering the cell nucleus.
• Gut Health & Mucosal Barrier: In mouse models of colitis, KPV is observed for its interaction with the PepT1 transporter. Researchers utilize it to study the maintenance of intestinal lining integrity during stress.
• Antimicrobial Activity: In vitro (test tube) studies have shown KPV exhibits activity against specific bacteria and fungi (including C. albicans). It is a key variable in research regarding the body’s natural defense against pathogens.
• Synergistic Pairing: KPV is frequently studied alongside BPC-157. Researchers often compare KPV’s anti-inflammatory mechanism against BPC-157’s tissue-repair mechanism.

Technical Data

• Sequence: Lys-Pro-Val (KPV)
• Molecular Formula: C₁₆H₃₀N₄O₄
• Molecular Weight: ~342.43 g/mol
• Purity: >99% (HPLC Verified)
• Appearance: White to off-white lyophilized powder
• Solubility: Highly Water Soluble

Storage & Handling

• Lyophilized (Powder): Store at -20°C for up to 24 months.
• Reconstituted (Liquid): Store at 4°C. Use within 28 days to ensure peptide stability.
• Hygroscopic Nature: This peptide absorbs moisture from the air. Allow the vial to reach room temperature before opening.

References

• Dalmasso, G., et al. (2008). “PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.” Gastroenterology, 134(1), 166-178. PubMed Link
• Cutuli, M., et al. (2000). “Antimicrobial effects of alpha-MSH peptides.” Journal of Leukocyte Biology, 67(2), 233-239. PubMed Link

Certificate of Analysis (COA): Manufacturer Verified >99% (PDF Update Pending)